Nicht-alkoholische Fettleber: Prävention und Therapie mit Ernährung und Nährstoffen

Zusammenfassung

Die nicht-alkoholische Fettlebererkrankung (NAFLD) ist die häufigste chronische Lebererkrankung in Industrieländern. Neben Übergewicht, Typ-2-Diabetes und metabolischem Syndrom spielen auch die Ernährung sowie Mikronährstoffe eine zunehmende Rolle in Prävention und Therapie. Dieser Artikel beleuchtet die wissenschaftlich gesicherte Evidenz zu Vitamin E, Omega-3-Fettsäuren, Vitamin D und der bioaktiven Substanz Curcumin im Kontext der NAFLD.

Schlüsselwörter

NAFLD - Fettleber - Ernährung - Mikronährstoffe - Vitamin E - Omega-3 - Vitamin D - Selen - Insulinresistenz - Lebergesundheit

Publication History

Article published online:
07 July 2025

• Literatur

• 1 Ryan CR. et al. The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. J Hepatol 2013; 59: 138-143
• 2 Sanyal AJ. et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010; 362: 1675-1685
• 3 Yan JH. et al. Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials. Medicine (Baltimore) 2018; 97: e12271
• 4 de Castro GS. et al. Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. Clin Nutr 2018; 37: 37-55
• 5 Boyraz M. et al. Long-term treatment with n-3 polyunsaturated fatty acids as a monotherapy in children with nonalcoholic fatty liver disease. J Clin Res Pediatr Endocrinol 2015; 7: 121-127
• 6 Gao M. et al. Fish consumption and n-3 polyunsaturated fatty acids, and risk of hepatocellular carcinoma: systematic review and meta-analysis. Cancer Causes Control 2015; 26: 367-376
• 7 Liu S. et al. Association between vitamin D status and non-alcoholic fatty liver disease: A population-based study. J Nutr Sci Vitaminol (Tokyo) 2019; 65: 303-308
• 8 Hussain M. et al. Effect of vitamin D supplementation on various parameters in non-alcoholic fatty liver disease patients. Pak J Pharm Sci 2019; 32: 1343-1348
• 9 Vajdi M. et al. Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Rev 2025; 83: 1-12